INDICATIONS in Females

• Induction and Synchronization of Estrus: Used to bring female animals into heat simultaneously to facilitate artificial insemination and management efficiency in pigs (sows and gilts), cattle, sheep, and goats.
• Superovulation: Stimulates the development of multiple follicles to increase the number of eggs produced. This is a critical step in embryo transfer programs in cattle and sheep.
• Treatment of Anestrus: Indicated for animals failing to show a normal estrous cycle, such as non-cycling cows, heifers, or weaned sows experiencing a delayed return to heat.
• Increase in Prolificacy: Administered to small ruminants (sheep and goats) to increase litter size by promoting multiple ovulations.
• Induction of Puberty: Used in prepuberal gilts (pigs) and other livestock to trigger the onset of sexual maturity.
• Receptivity Optimization: In species like rabbits and minks, it is used to improve reproductive performance and receptivity. 

• Spermatogenesis Stimulation: Occasionally used to treat impaired sperm production in bulls, stallions, boars, rams, and dogs, though its efficacy in these cases is often reported as low. 

• Cattle: Induction/synchronization of ovulation and superovulation for embryo transfer.
• Pigs: Induction of fertile estrus in prepuberal gilts and weaned sows; reducing weaning-to-estrus intervals.
• Sheep & Goats: Synchronization of heat outside the normal breeding season and increasing lambing rates.
• Dogs & Cats: Induction of estrus in subnormal or non-receptive animals.
• Laboratory Animals: Widely used in mice and rats for superovulation and research into cell differentiation. 

ADMINISTRATION

• Reconstitution: PMSG is typically supplied as a freeze-dried powder (lyophilisate) and must be reconstituted immediately before use.
• Preparation: Use a sterile needle and syringe for preparation and administration. Do not use chemical sterilization.
• Administration: The injection is given deep into a muscle for IM administration, or just under the skin for SC administration.
• Disposal: The solution should be used immediately after preparation, and any unused portion, along with the vials and needles.
• Cattle: PMSG can be administered via intramuscular or subcutaneous injection, often in the neck area (a preferred site for injections).
• Sheep and Goats: In ewes and does, it is typically given by subcutaneous or intramuscular injection at the time of progestagen sponge removal.
• Pigs (Sows): Administration is generally intramuscular (e.g., behind the base of the ear) or subcutaneous.
• Dogs (Bitches): PMSG is generally given by subcutaneous injection.