NexGard COMBO (esafoxolaner, epinomectin, praziquantel) is a veterinary medication for cats that is a spot-on treatment for combating mixed parasitic infections. It targets fleas, ticks, ear mites, roundworms, and tapeworms, and is used when cats are at risk from, or suffering from, these combined infestations. Contains esafoxolaner, which is a member of the isoxazoline class.