• Endocrine Disorders: Primary or secondary adrenocortical insufficiency (used as a replacement therapy alongside mineralocorticoids) and hypercalcemia associated with cancer.
• Rheumatic and Collagen Diseases: Management of psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, gout, and systemic lupus erythematosus.
• Allergic States: Control of severe allergic conditions, including bronchial asthma, seasonal or perennial allergic rhinitis, and drug hypersensitivity reactions.
• Dermatologic Diseases: Treatment of severe skin conditions such as pemphigus, severe psoriasis, bullous dermatitis herpetiformis, and severe erythema multiforme (Stevens-Johnson syndrome).
• Ophthalmic Diseases: Severe, acute, and chronic inflammatory and allergic eye processes, including optic neuritis, iritis, keratitis, and allergic conjunctivitis.
• Respiratory Diseases: Management of symptomatic sarcoidosis, berylliosis, and aspiration pneumonitis.
• Hematologic Disorders: Treatment of idiopathic thrombocytopenic purpura, acquired (autoimmune) hemolytic anemia, and certain types of anemia in adults.
• Neoplastic Diseases: For palliative management of leukemias and lymphomas in adults and acute leukemia of childhood.
• Gastrointestinal Diseases: To manage critical periods of ulcerative colitis and regional enteritis (Crohn’s disease).
• Edematous States: To induce diuresis (increased urine production) or remission of proteinuria in nephrotic syndrome.
• Neurological Disorders: Treatment of acute exacerbations of multiple sclerosis. 

ADMINISTRATION

• Dosing: Measure the liquid form carefully using the provided measuring device (usually a syringe or dropper) to ensure accuracy.
• Timing: Administer the medication at approximately the same time each day to maintain a stable level of the drug in the body.
  • For dogs, once-daily doses are often recommended in the morning.
  • For cats, once-daily doses are often recommended in the evening, aligning with their natural hormone cycles.
• With Food: Give with food or immediately after a meal to help minimize the risk of stomach upset or gastrointestinal ulcers.
• Missed Dose: If a dose is missed, give it as soon as you remember. If it is close to the time for the next scheduled dose, skip the missed dose and resume the regular schedule. Do not give a double dose.
• Do Not Stop Abruptly: Never stop administering the medication suddenly, especially after long-term use, as this can lead to severe, potentially life-threatening complications. The pet must be gradually weaned off the drug under veterinary supervision.