Vanguard CPV (canine parvovirus, strain NL-35-D, live) is used for the active immunisation of healthy puppies and dogs to prevent clinical signs including leucopenia and reduce viral shedding caused by canine parvovirus (type 2a), to prevent mortality and clinical signs including leucopenia, and to reduce viral shedding caused by canine parvovirus (types 2b and 2c).