Intas PragmaD (D-Cloprostenol) is a synthetic prostaglandin analogue indicated for use in cattle, pigs, and horses.
INDICATIONS (For cattle)
- Estrus Synchronization/Induction: The primary use is to synchronize the estrus cycles of a group of animals to allow for scheduled breeding or fixed-time artificial insemination (FTAI). It can also be used in individual cows not showing visible signs of heat (suboestrus/non-detected estrus) despite having normal ovarian cycles.
- Treatment of Ovarian Dysfunction: It helps resolve conditions involving a persistent corpus luteum, such as luteal cysts or an absence of estrus (anoestrus).
- Treatment of Uterine Conditions: The medication is indicated for uterine disorders related to a functioning corpus luteum, including pyometra (an accumulation of pus in the uterus) and chronic endometritis.
- Pregnancy Termination/Management:
- Induction of Abortion: It can safely and efficiently terminate unwanted pregnancies, typically within the first half (up to around 5 months) of gestation.
- Expulsion of Mummified Fetus: It helps induce the expulsion of a dead, dehydrated fetus from the uterus.
- Induction of Parturition: It can be used to induce labor after the 270th day of gestation.
- Delayed Uterine Involution: It aids in the uterus returning to its normal size and function postpartum.
For Pigs (Sows)
In sows, D-Cloprostenol injection is primarily indicated for the induction of farrowing (parturition), usually after the 114th day of gestation, to better manage birthing schedules and herd productivity.
For Horses (Mares)
For mares, the injection is used to induce luteolysis (regression of the corpus luteum) in animals with a functional corpus luteum. This action helps manipulate the estrus cycle for breeding management.
D-Cloprostenol Injection is administered via intramuscular injection to livestock (primarily cattle, pigs, and horses) to induce luteolysis (regression of the corpus luteum). This action manipulates the reproductive cycle for breeding management and treating specific conditions associated with prolonged luteal function.
ADMINISTRATION
- Route: The medication is given via deep intramuscular injection.
- Aseptic Technique: Careful aseptic techniques must be employed to minimize the risk of bacterial infections at the injection site.
- Needle Placement: The injection should be delivered deep into a muscle, typically in the neck area for cattle to preserve higher-value cuts of meat. The needle should be inserted at a 90-degree angle to the skin surface.
- Dosage: The dosage is species-specific. For example, in cattle, a typical dose is 2 mL (150 mcg of d-cloprostenol), while in sows and mares, it’s often 1 mL (75 mcg).
- Safety Precautions: The drug can be absorbed through the skin and may cause bronchospasms or abortion in humans. Handle product with extreme caution, avoid direct skin contact, use waterproof gloves.
