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D-L Cloprostenol

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D-L Cloprostenol

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Parnell estroPLAN Injection

Parnell estroPLAN (cloprostenol sodium) is a prostaglandin analogue used in beef and dairy cattle to induce luteolysis, manipulate the estrous cycle, and synchronize ovulation for timed artificial insemination (TAI). A WVA Veterinary Medicine.

Parnell estroPLAN is a prostaglandin analogue used in beef and dairy cattle to induce luteolysis, manipulate the estrous cycle, and synchronize ovulation for timed artificial insemination.

INDICATIONS (For Cattle)

  • Estrus Synchronization: Used to synchronize estrus in cycling beef and dairy cows and heifers.
  • Unobserved/Non-detected Estrus: Used to induce estrus in cows that are cycling but not observed in heat (when a mature corpus luteum is present).
  • Reproductive Conditions: Treatment of luteal cysts, pyometra, or chronic endometritis.
  • Mummified Fetus: Expulsion of a mummified fetus.
  • Termination of Pregnancy: Safely terminates unwanted pregnancies (mismating) from 1 week after mating up to 5 months of gestation.
For Pigs (Sows)
  • Induction of Parturition (Farrowing): Used to induce farrowing in sows and gilts to manage and synchronize farrowing schedules. 
For Horses (Mares)
  • Induction of Luteolysis: Used in mares with a functional or persistent corpus luteum to induce a return to estrus and normal ovulation, which aids in stud management.
  • Termination of Pregnancy: Can be used to terminate pregnancy in the early stages, though this application requires careful veterinary supervision. 

ADMINISTRATION

  • Cattle (Beef and Dairy): Administered via intramuscular injection.
  • Horses (Ponies and Donkeys): Administered by intramuscular injection.
  • Horses (Thoroughbreds/Heavy Horses): Administered by intramuscular injection.
  • Estrus Synchronization: Often used in a “double injection” regimen, where a second dose is given after the first.
  • Fixed Time AI (FTAI): Can be used in combination with gonadorelin (e.g., GONAbreed).
  • Pregnancy Termination: For abortion in cattle, administered via IM injection between 1 week after mating and 5 months of gestation.
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