ADMINISTRATION

• Intramuscular (IM) Injection: This is a common route for veterinary use, such as treating trypanosomiasis in dogs. It should be administered as a deep IM injection into a large muscle mass.
• Intravenous (IV) Infusion: Pentamidine can be given intravenously, but it must be administered as a slow infusion over 60 to 120 minutes. Rapid IV bolus must be avoided, as it can cause life-threatening hypotension or collapse.
• Inhalation (Aerosol): While less common in general veterinary practice, pentamidine isethionate can be administered via a nebulizer for localized lung treatment or prophylaxis (e.g., in experimental models like rats or dogs).