Dogs
In dogs, the injectable solution is approved as an initial dose (followed by oral tablet therapy) for specific infections caused by susceptible bacterial strains: 

• Dermal infections (wounds and abscesses).
• Respiratory infections (pneumonia, tonsillitis, rhinitis).
• Urinary cystitis (bladder infections). 

ADMINISTRATION

• Mechanism of Action: Enrofloxacin is a fluoroquinolone that works by inhibiting bacterial DNA gyrase, which prevents the bacteria from replicating and causes cell death.
• Targeted Infections: It is effective against various Gram-negative and Gram-positive bacteria associated with dermal, respiratory, and urinary tract infections, as well as gastrointestinal infections and septicaemia.
• Administration Routes:
  • Cattle: Subcutaneous (SC) or slow intravenous (IV) injection.
  • Swine: Intramuscular (IM) injection (typically in the neck near the ear base) or subcutaneous injection.
  • Dogs: Intramuscular injection, typically as a single initial dose, which is then followed by oral tablet therapy 12 hours later. It is not approved for use in cats due to the risk of retinal toxicity, though veterinarians may use it extra-label with extreme caution.
  • Other species: It is used extra-label (off-label) in various other species like sheep, goats, rabbits, horses, and some exotic animals under veterinary supervision.