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Enrofloxacin

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Enrofloxacin

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ENROSAFE Enroflozacin Injection

ENROSAFE Enrofloxacin is a broad-spectrum antibiotic used to treat bacterial infections in cattle and swine. A WOAH Veterinary Medicine.

ENROSAFE Enrofloxacin is a broad-spectrum antibiotic used to treat bacterial infections in cattle, and swine.

INDICATIONS

Cattle (Beef and Non-Lactating Dairy)
In cattle, enrofloxacin injection is indicated for the treatment and control of Bovine Respiratory Disease (BRD) associated with specific bacterial pathogens (e.g., Mannheimia haemolytica, Pasteurella multocida, Histophilus somni, and Mycoplasma bovis). can be used as a single-dose or multiple-day therapy. 
Swine
Indicated for the treatment and control of Swine Respiratory Disease (SRD) and for the control of colibacillosis associated with Escherichia coli. 

ADMINISTRATION

  • Mechanism of Action: Enrofloxacin is a fluoroquinolone that works by inhibiting bacterial DNA gyrase, which prevents the bacteria from replicating and causes cell death.
  • Targeted Infections: It is effective against various Gram-negative and Gram-positive bacteria associated with dermal, respiratory, and urinary tract infections, as well as gastrointestinal infections and septicaemia.
  • Administration Routes:
    • Cattle: Subcutaneous (SC) or slow intravenous (IV) injection.
    • Swine: Intramuscular (IM) injection (typically in the neck near the ear base) or subcutaneous injection.
    • Dogs: Intramuscular injection, typically as a single initial dose, which is then followed by oral tablet therapy 12 hours later. It is not approved for use in cats due to the risk of retinal toxicity, though veterinarians may use it extra-label with extreme caution.
    • Other species: It is used extra-label (off-label) in various other species like sheep, goats, rabbits, horses, and some exotic animals under veterinary supervision. 
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