Human Chorionic Gonadotropin (hCG) is indicated for the treatment of various reproductive disorders in cattle and horses.

• Induction of Ovulation: This is a major use, particularly in mares and cows in controlled-breeding and artificial insemination programs, to time breeding accurately and improve conception rates.
• Treatment of Ovarian Disorders:
  • In cows, it is specifically approved for the treatment of nymphomania (frequent or constant heat behavior) caused by cystic ovaries.
  • It is also used to induce the regression of ovarian cysts in guinea pigs and other small mammals.
• Stimulation of Gonadal Function (Males):
  • It is used in male animals (dogs, horses, goats) to stimulate testosterone production by Leydig cells, which helps in the diagnosis of cryptorchidism (retained testicles) or to test testicular function.
  • Low-dose injections have also shown promise in improving semen quality in dogs with certain dysfunctions.
• Pregnancy Support and Synchronization Protocols: It can be part of broader synchronization protocols in cattle to promote the formation of accessory corpora lutea, increase progesterone levels, and potentially enhance pregnancy rates.
• Other Species:
  • In finfish, it is licensed to assist spawning behavior.
  • It has been used to induce ovulation in ferrets with persistent estrus and to manage certain reproductive issues in avian species (hens).

• HCG is a protein, and repeated use in some species (like cattle or cats) can lead to an antibody response, which may reduce effectiveness or cause allergic reactions.
• No withdrawal period is typically required for cows or finfish treated according to label directions.
• Treatment should always be performed under the guidance of a qualified veterinarian.