• Estrus Synchronization (Cattle): Used to synchronize the estrous cycle in cattle, often in conjunction with progesterone, to facilitate artificial insemination.
• Treatment of Anestrus: Used in female animals (such as mares) to stimulate behavioral estrus.
• Mismating/”Mis-mate” Shot (Dogs): Historically used in bitches shortly after unwanted breeding to prevent pregnancy, although this use is now less common due to potential side effects like pyometra and bone marrow suppression.
• Urinary Incontinence (Dogs): Used at low doses to treat hormone-responsive incontinence in spayed female dogs.
• Growth Promotion (Livestock): Used as an ear-implant ingredient to increase the rate of weight gain and improve feed efficiency in cattle.
• Induction of Lactation: Used in non-pregnant cows with reproductive failures to induce lactation.

ADMINISTRATION

• Method: The powder is dissolved in an oil-based vehicle (such as sesame oil) and injected subcutaneously.
• Use: Often used for short-term studies or specifically designed pulsed administration to mimic natural hormonal fluctuations.
• Duration: Oil-based injections allow slow absorption, but may require repeated handling to maintain stable levels. 

• Method: The powder is formulated into a small solid pellet or filled into silastic capsules and implanted subcutaneously, frequently at the back of the ear in cattle.
• Use: Primarily used for long-term delivery to increase weight gain and improve feed efficiency in livestock.
• Mechanism: These implants are designed for slow-release over an extended period. 

• Method: Dissolved in an oil-based carrier and injected directly into the muscle.
• Use: Frequently used in equine medicine or to synchronize estrus in cattle.