Streptomycin is an aminoglycoside antibiotic indicated for the treatment of infections in livestock and companion animals.

INDICATIONS

• Leptospirosis: An important zoonotic disease in cattle, pigs, and sheep, where streptomycin helps eliminate the carrier state, reducing transmission risk to humans and other animals.
• Brucellosis and Tularemia: Systemic bacterial infections.
• Respiratory tract infections: Including pneumonia and bronchopneumonia caused by susceptible organisms like Pasteurella spp. and Klebsiella pneumoniae.
• Genitourinary tract infections: Such as endometritis, metritis, pyometra, cystitis, and nephritis.
• Gastrointestinal tract infections: Including bacterial diarrhea and enteritis caused by Salmonella spp. or E. coli.
• Mastitis: Inflammation of the udder, often caused by bacterial infections.
• Septicemia: Generalized bacterial infection of the bloodstream.
• Wound and postnatal sepsis.
• Erysipelas and edema in pigs.
• Actinomycosis and actinobacillosis (“wooden tongue”) in cattle.
• Navel/joint ill in young animals.
• Tuberculosis: In specific cases and often as a second-line or adjunctive treatment. . 

ADMINISTRATION

• Route: Administered parenterally, with the intramuscular (IM) route being common for rapid and complete absorption.
• Dosage: Dosage and treatment duration depend on the animal’s species, weight, age, and the severity of the infection, and should not exceed three to five days with combination products. 
• Reconstitution (if powder): Dissolve the powder using a sterile diluent such as water for injection or sterile saline. Standard ratios are typically 4 mL of solvent per 1 gram of powder.
• Preparation: Shake the vial well before drawing the dose to ensure a homogenous mixture, especially for suspensions.
• Injection Technique:
  • Route: Administer strictly by deep intramuscular injection.
  • Site: Use large muscle groups (e.g., neck or gluteal muscles in livestock).
  • Rotation: Always rotate injection sites if multiple doses are required.
  • Post-Injection: Massage the site gently after administration to aid absorption.