INDICATIONS (For Cattle)

• Estrus Synchronization and Induction: Used to schedule estrus (heat) and ovulation in cycling cows and heifers for controlled breeding and artificial insemination programs.
• Treatment of Ovarian Dysfunctions: Effective in managing conditions like unobserved/non-detected estrus (“silent heat”) and ovarian luteal cysts, which are associated with a persistent CL.
• Treatment of Uterine Conditions: Used as part of therapy for chronic endometritis and pyometra (uterine infection characterized by purulent matter accumulation), as it helps the uterus evacuate its contents.
• Termination of Pregnancy: Can be used to safely and efficiently terminate unwanted pregnancies (mismating) up to a certain stage of gestation (typically the first 4 to 5 months).
• Management of Abnormal Pregnancy: Aids in the expulsion of a mummified fetus.
• Induction of Parturition: Can be administered to induce labor around the normal term of gestation. 

• Induction of Parturition (Farrowing): Used to induce farrowing in sows and gilts to manage and synchronize farrowing schedules. 

• Induction of Luteolysis: Used in mares with a functional or persistent corpus luteum to induce a return to estrus and normal ovulation, which aids in stud management.
• Termination of Pregnancy: Can be used to terminate pregnancy in the early stages, though this application requires careful veterinary supervision. 

ADMINISTRATION

• Route: Deep intramuscular injection is the standard route of administration.
• Aseptic Technique: Careful aseptic techniques must be used to minimize the risk of post-injection bacterial infections, which can be severe in rare cases.
• Equipment: A standard needle and syringe are used, though needle-free injection systems have also been shown to be effective. For multi-dose vials, the use of a multiple-dose syringe or a suitable draw-off needle is recommended to avoid excessive stopper punctures.
• Dosage: The specific dosage (e.g., 2 mL in cattle or swine) depends on the animal species and the condition being treated (e.g., estrus synchronization, pyometra, abortion).