Gonadorelin injection (GnRH) is indicated for use in cattle and pigs for the treatment of ovarian follicular cysts, and for synchronizing estrous cycles.
INDICATIONS (Cattle)
- Treatment of ovarian follicular cysts: It is indicated for treating non-ovulated follicles that cause irregular estrus or nymphomania by initiating the release of endogenous LH to cause ovulation and luteinization of the cyst.
- Synchronization of estrous cycles: It is a key component in reproductive synchrony programs (e.g., in combination with cloprostenol sodium/dinoprost tromethamine) to allow for fixed-time artificial insemination (FTAI).
- Improvement of postpartum fertility: Administration in the early postpartum period can stimulate the resumption of normal estrous cycles and reduce the incidence of cystic ovarian disease.
- Induction/Prevention of delayed ovulation: It can be used to induce ovulation in cows with a developed follicle and to prevent delayed ovulation, thus improving conception rates.
- Control of the reproduction cycle: Used in anestrous cows to induce follicle growth and maturation.
OTHER ANIMALS
- Dogs: Gonadorelin injection can be used to induce ovulation in females and to treat cryptorchidism (undescended testicles) in males.
- Rabbits: It is used for ovulation induction.
ADMINISTRATION
- Route: It is commonly administered as an intramuscular (IM) injection, but some products can be given intravenously (IV). The injection site in cattle is usually the anterior half of the neck.
- Dosage: The dosage varies by product and indication, but common doses for cattle are 86 mcg or 100 mcg per cow per injection.
- Regimen: For estrous synchronization, it is part of a multi-day protocol involving multiple injections of gonadorelin and prostaglandin at specific intervals to control the timing of ovulation and artificial insemination.
