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Baquiloprim

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Baquiloprim

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Buparvaquone Injection

Baquiloprim (Buparvaquone) is an injectable antiprotozoal drug primarily used in cattle for the treatment and prevention of theileriosis, also known as East Coast fever or tropical theileriosis. It is considered the gold standard treatment for these tick-borne diseases in endemic regions of Africa, the Middle East, Southern Europe, and Asia. A WOAH Veterinary Medicine.

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Buparvaquone (Baquiloprim) is primarily indicated for the treatment and prevention of tick-transmitted theileriosis in cattle.

INDICATIONS

Buparvaquone is highly effective against all forms of theileriosis caused by various Theileria species (e.g., T. parva, T. annulata, T. orientalis).

  • Theileria parva: The cause of East Coast fever, Corridor disease, and Zimbabwean theileriosis.
  • Theileria annulata: The cause of tropical theileriosis.
  • Theileria orientalis: Also effective against this species.
  • Theileria mutans and Theileria sergenti. 
  • Works by inhibiting the parasite’s mitochondrial electron transport chain, which blocks its respiration and energy production, killing both the schizont and piroplasm stages of the parasite.

ADMINISTRATION

  • Typically administered as a single intramuscular injection into the neck muscles.
  • Route: Intramuscular (IM) injection only.
  • Site: The injection should be given deep into a large muscle mass; the neck muscles in cattle are the recommended site. For dogs and cats, it can be injected into the muscles as well.
  • Volume per Site: No more than 10 ml should be injected into a single site. If the required dose exceeds this volume, it should be divided into smaller portions and administered at different, successive injection sites.
  • Severe Cases: In severe or advanced cases, a second treatment may be required 48 to 72 hours after the initial injection, at the same dose rate and a different site.

DOSING

  • In severe or advanced clinical cases, a second injection may be necessary 48 to 72 hours after the initial dose. No more than 10 ml should be injected into a single site.
  • When used early in the course of the disease, it has a high recovery rate (90-98%). It helps the animal survive the acute infection, allowing it time to develop its own protective immunity, though the animal often remains a lifelong carrier. 

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