NexGen Magnesium sulfate is used to treat hypomagnesaemia, as an anticonvulsant, muscle relaxant, and electrolyte replacement in livestock and companion animals.

INDICATIONS

• Electrolyte Replacement: It is the primary treatment for hypomagnesemia (low magnesium levels in the blood), which can be life-threatening, particularly in cattle and sheep (known as “grass tetany” or “staggers”).
• Anticonvulsant/Muscle Relaxant: It controls seizures and muscle spasms by blocking neuromuscular transmission.
  • A potential adjunct therapy for managing severe generalized tetanus in dogs.
  • Can help manage seizures associated with eclampsia/pre-eclampsia in pregnant animals.
• Cardiac Arrhythmias: It may be administered to treat life-threatening ventricular arrhythmias or torsades de pointes in dogs, cats, and horses, typically via slow intravenous (IV) injection.
• Anesthetic Adjunct: When used during anesthesia, it can reduce the amount of other anesthetic agents needed, potentially improving cardiovascular stability and recovery times.
• Pain Management: It has been investigated for its neuroprotective and analgesic effects in horses, showing promise in treating conditions like trigeminal-mediated headshaking (facial pain).
• Malignant Hyperthermia: In pigs, it is used to reverse malignant hyperthermia syndrome. 

ADMINISTRATION

• Intravenous (IV) Injection/Infusion: Used for immediate, systemic effects such as controlling seizures, treating arrhythmias, or during anesthesia. The injection is typically given slowly or as a constant rate infusion and must be diluted properly.
• Intramuscular (IM) Injection: Results in a slower onset but longer duration of action for systemic effects.
• Subcutaneous (SC) Injection: This route is sometimes used for large volumes of cattle and sheep to treat grass tetany, often in the neck or over the ribs.